PIEZO1 and acute respiratory distress syndrome: Therefore, we examined whether Piezo1 explained part of this function of LTV by ventilating oleic acid injected rats with either LTV(Vt 6cmH2O/kg, PEEP 3cmH2O)or high tidal volume ventilation HVT(Vt 15cmH2O/kg, PEEP 0cmH2O).Rats with LTV presented less severe ARDS and lung injury(Fig. 4a Additional file 1: Figure S3) In addition, the apoptosis of type II pneumocytes was significantly reduced in LTV rats compared with HVT rats(Fig. 4b) Notably, we observed less expression of Piezo1 in LTV rats.