To investigate the role of Piezo1 in ARDS, the oleic acid-induced ARDS model was established in rats and confirmed by assessing oxygenation index, wet/dry ratio, HE staining(Fig. 2a) and other indicators(Additional file 1: Figure S1A) We next compared Piezo1 expression between control and ARDS rats, and found that Piezo1 was significantly increased in the ARDS group(Fig. 2b), indicating that Piezo1 may play a role in ARDS progression. Here, PIEZO1 is linked to acute respiratory distress syndrome.