However, CTHRC1 and FHL2 levels in the normal control fibroblast did not change upon TGF-β1 stimulation (CTHRC1: control, P = 0.109 versus lung fibrosis, P = 0.003; FHL2: control, P = 0.360 versus lung fibrosis, P = 0.006; Fig. 3A, B), which suggested that fibrotic fibroblasts specifically responded to TGF-β1 stimulation as previously described [11]. This evidence concerns the gene CTHRC1 and pulmonary fibrosis.