Interestingly, the expressions of NOTCH1, NOTCH2 or NOTCH3 are highly correlated with those of many prognostic immune receptors (Additional file 2: Figure S5), implying that Notch signaling might be important in the regulation of tumor immune response or tumor microenvironment, which, in fact, has been reported in many studies [42, 43]. Here, NOTCH2 is linked to neoplasm.