Deriving a similar model without CA-125 level as a predictor mainly affected discrimination between stage II-IV cancer and other malignancies: validation AUCs decreased from 0.82 to 0.59 (stage II-IV cancer v metastatic cancer), from 0.87 to 0.76 (stage II-IV cancer v stage I cancer), and from 0.95 to 0.91 (stage II-IV cancer v borderline tumors) [29]. The gene discussed is MUC16; the disease is cancer.