KL and chronic kidney disease: With regards to patients with CKD, Seiler et al. have previously, shown in 312 patients with CKD stages 2 to 4, that levels of Klotho did not predict the occurrence of death or the initiation of renal replacement therapy during 2.2 years, (HR for logarithmic transformed Klotho 1.46, 95%CI 0.14–15.95, [18].