In contrast, a recent study in 168 patients with type 2 diabetes, followed for 7 years, showed that low Klotho is associated with macrovascular outcomes, as patients in the highest compared to the lowest quartile of Klotho levels had HR:0.471, 95%CI 0.307–0.725, p = 0.001 for the combined outcome of macrovascular complications (including coronary artery disease, cerebrovascular attacks and peripheral artery occlusive disease, with significant differences present also for the individual components [17]. The gene discussed is KL; the disease is Peripheral arterial stenosis.