Exon 19 deletions and exon 21 missense mutations are common EGFR activating mutations, and among these, exon 19 in-frame deletions and the L858R exon 21 missense mutation have been shown to represent approximately 80% of the EGFR-TKI-sensitive mutations in NSCLC [6]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.