The effectiveness of non-CTCs demarcation can be strengthened by combining targeting of CD45 with other biomarkers, like those specific for myeloid cells (CD11b), tumor-associated macrophages (CD68), erythrocytes (CD235a), endothelial cells (CD146), and hematopoietic stem cells (CD34) [56,57]. The gene discussed is ITGAM; the disease is neoplasm.