SLC22A12 and hyperuricemia: Previous studies have shown that the expression levels of the two transporters, GLUT9 and URAT1, in the kidney were significantly increased in the PO (300 mg/kg)-induced hyperuricemia group, but the higher GLUT9 and URAT1 protein levels in the hyperuricemia group were reduced by intervention with luteolin (20, 40, 100 mg/kg) [20].