As basic epilepsy research and genetic screening techniques have improved more than 400 genetic mutations associated with epilepsy have been identified, including SCN1A, SCN2A, SCN3A, SCN8A, SCN9A, SCN1B, KCNQ2, KCNQ3, KCTD7, CACNA1H, CLCN2, GABRA1, GABRB3, GABRG2, SLC2A1, CDKL5, ARX, CHD2, STXBP1, and PNPO [25,26,27]. This evidence concerns the gene PNPO and epilepsy.