Framingham Study participants without HF were revealed to have mean BNP levels in lean (<25 kg/m2), overweight (25 to 29.9 kg/m2), and obese (≥30 kg/m2) men of 21.4, 15.5, and 12.7 pg/mL, respectively (trend p < 0.0001) [45]. The gene discussed is NPPB; the disease is hydrops fetalis.