NPPB and atrial fibrillation: In the ARISTOTLE trial including 18,201 patients with AF, adding NT-proBNP levels to the CHA2DS2-VASc score improved the C-statistic from 0.62 to 0.65 (p = 0.0009) for stroke or systemic embolism and from 0.59 to 0.69 for cardiac death (p < 0.0001) [95].