Similarly, in the large prospective study of the Framingham Offspring study, which included 3346 people without HF (mean follow-up of 5.2 years), those with a BNP above the 80th percentile (20.0 pg/mL for men and 23.3 pg/mL for women) were associated with multivariable-adjusted hazard ratios (HRs) of 1.62 for death, 1.76 for a first major cardiovascular event, 1.91 for AF, 1.99 for stroke or transient ischemic attack, and 3.07 for HF [26]. The gene discussed is NPPB; the disease is Stroke.