In a comparison between HFrEF (EF ≤50%) and HFpEF (EF >50%) in 160 consecutive patients presenting with HF, the BNP level was significantly higher in those with HFrEF compared with those with HFpEF (267 (136–583) and 105 (64–146) pg/mL, respectively, p < 0.001) [32]. Here, NPPB is linked to hydrops fetalis.