NPPB and hydrops fetalis: In another study of 78 patients seen at a single HF clinic, BNP significantly increased according to different NYHA functional classes (class I: 21.6 ± 2.8 pg/mL, class II: 108.6 ± 16.3 pg/mL, class III: 197.1 ± 27.2 pg/mL, and class IV: 363.0 ± 67.8 pg/mL, p < 0.0001).