In the RE-LY trial including 6189 patients, rates of stroke were independently related to levels of NT-proBNP (2.30%/year vs. 0.92%/year in the highest (>1402 pg/mL) versus lowest (<387 pg/mL) quartile groups, HR, 2.40 (95% CI, 1.41–4.07), p = 0.0014) [94]. Here, NPPB is linked to Stroke.