RD and the self- aggregating, pro- inflammatory process ultimately leads to proliferative vitreoretinopathy (PVR) formation, and as such, the presence of pro-inflammatory, fibrotic factors were found in the SRF (Chitinase 3-like 1, DPPIV, FGF-19, Serpin E1 [PAI-1], uPAR) along with other potent inducers of angiogenesis (Angiogenin, CD31, Endoglin, HGF, IL-8, SDF-1a, VEGF). This evidence concerns the gene ENG and CAPN5-related vitreoretinopathy.