Given that schizophrenia is associated with increased levels of both H3K9me2 and HMT mRNA [20], and these repressive insults are associated with both schizophrenia symptoms, and cognitive and learning deficits, this manuscript sought to establish the potential therapeutic value of the G9a and GLP inhibitor BIX-01294 (BIX) as a means of relieving restrictive epigenome characteristic of schizophrenia. The gene discussed is EHMT2; the disease is schizophrenia.