In the feasibility study, to examine if the same group of schizophrenia candidate genes examined in the human PBMC culture had altered expression in the cortex from animals treated with BIX (Vehicle, 0.5 or 1 mg/kg), we studied cortical mRNA changes in those same genes, with the addition of two brain-specific genes: Reln and Bdnf9a. The gene discussed is RELN; the disease is schizophrenia.