MAPK8 and systemic lupus erythematosus: The DUSP22, also known as JKAP (JNK pathway-associated phosphatase), inhibits T-cell proliferation and cytokine production by JNK activation.[47] In mouse model, the DUSP22 suppressed T-cell immune responses and the development of autoimmunity.[47] It was also found in human study, that downregulation of DUSP22 in T cells was associated with the disease activity in the individuals with systemic lupus erythematosus.[48]