ADAMTS13 and Cognitive impairment: Next, we studied the role of ADAMTS13 in APPPS1 mice by injecting recombinant adeno-associated virus serotype 8 (AAV8)-mediated expression of a murine ADAMTS13 variant (AAV8-ADAMTS13) into the hippocampi of 9-month-old APPPS1 mice, which already exhibited vascular damage, plaque deposition, and cognitive deficits [25,48,49].