(2011) reported that the RIP2/caspase-1 axis plays an important role in cell death in lethally challenged cerebral ischemia-reperfusion injury, Huntington’s disease, cerebral cortical neurons, the striatum, NSC-34 cells, ST14A cells and HeLa cells induced by H2O2, OGD, TNF-α/CHX, and other noxious, which is aggravated by the overexpression and ameliorated by the down expression of RIP2 and caspase-1. Here, TNF is linked to juvenile Huntington disease.