As a proliferation‐related gene, RGC‐32 expression can be induced by sublytic C5b‐9 in endothelial cells and smooth muscle cells and contributes to the proliferation of these cells.15, 43, 44 For example, Vlaicu et al have reported that RGC‐32 expression is increased in the human aortic atherosclerotic wall and related with C5b‐9 deposition and atherosclerosis progression. Here, RGCC is linked to atherosclerosis.