Dox treatment can also result in chemoresistant tumor‐cell populations overexpressing multidrug resistance related xenobiotic transporters including ABCB1 (MDR1, Pgp) and ABCC1 (MRP1) and others (ABCC2, ABCC3, ABCG2, and RALBP1).20 Furthermore, this treatment can differentially modify phosphorylated Akt kinase levels depending on the tumor cells type, which play important roles in the tumor cell survival. This evidence concerns the gene ABCC3 and neoplasm.