In total, 56% patients with CCND1 high expression contained low‐grade tumor group, but only 36% patients with CCND1 low expression contained low‐grade tumor (chi‐square test, P < 0.001; Figure 5B), indicating CCND1 mRNA level decreases with increasing ccRCC tumor grades (P < 0.001; Figure 5C). This evidence concerns the gene CCND1 and nonpapillary renal cell carcinoma.