CCND1 and invasive breast carcinoma: Previous studies have shown that patients bearing tumors with high amplification of CCND1 had an increased risk of recurrence for invasive breast cancer and high expression of CCND1 predicts recurrence in supratentorial ependymomas.19, 45 Using the median expression as the cutoff point, we tested the probability of tumor recurrence in ccRCC patients with low and high expression of CCND1.