Stimulation of tuber‐derived cells with IL‐1β resulted in higher mRNA expression of MMP3, though it did not affect the mRNA expression of MMP2, MMP9 and MMP14. This might be explained by the fact that the cells, taken from the cortical tubers of TSC patients, already exhibit a high amount of MMP2, MMP9 and MMP14 transcripts and are therefore not sensitive to further induction by pro‐inflammatory molecules. Here, IL1B is linked to tuberous sclerosis.