This analysis revealed that the A-SAA–TLR2 pathway was induced in senescence activated by acute stresses, such as therapy-induced senescence in lymphoma cells (38), BRAFV600E-induced senescence in human melanocytes (39), stasis in primary human mammary epithelial cells (40), and DDR-induced senescence in human dermal fibroblasts (BJ) (41), while it was not induced in replicative senescence (41) and programmed developmental senescence in the murine mesonephros (Fig. 4H) (42). This evidence concerns the gene SAA1 and lymphoma.