CD40 and cardiovascular disorder: Otherwise, to the best of our knowledge, rs11086998 has not been associated as a genetic risk factor in cardiovascular diseases, but it is known to be related in the modulation of the levels of proinflammatory cytokines, TNFα and IL-6, because it resides on exon 9 encoding the intracellular domain protein implicated in signaling pathways of CD40 [34].