Low numbers (<20/1x106 spleen cells) of tumour antigen E7 specific CD8+ T cell responses are detected in the spleen of the tumour bearing mice; moreover, whether a strong INFγ response or a mixed IFNγ/IL-9 response is determined by the dosage of DCG spore administered intravenously to the TC-1 tumour bearing mice. This evidence concerns the gene IFNG and neoplasm.