The prevalence of 25-OH vitamin D insufficiency/deficiency is higher for children living in Turkey [9]. A recent study on children with asthma from Costa Rica showed a significant inverse association between the 25-OH vitamin D levels and use of anti-inflammatory medication (either inhaled corticosteroid or leukotriene inhibitor) in the previous year, total immunoglobulin E (IgE), and eosinophil count [10]. The gene discussed is IGHE; the disease is asthma.