Fourteen targets have been identified to be associated with cancer, which played an therapeutic role in treating cancer by regulating target proteins, such as erb-b2 receptor tyrosine kinase 2 (ERBB2), androgen receptor (AR), SRC proto-oncogene, nonreceptor tyrosine kinase (SRC), and epidermal growth factor receptor (EGFR), estrogen receptor 1 (ESR1), as well as proteoglycans in cancer, cancer pathways, and microRNAs in cancer and other pathways [11]. This evidence concerns the gene ESR1 and cancer.