IFNA1 and viral infectious disease: Moreover, our results also revealed that the recombinant VSV-GFP virus in 293T cells expressing ZIKV NS4A, DENV NS4A or IVA PB1-F2 exhibited a high-degree replication (Fig. 6b, c), suggesting that the inhibitory effect of ZIKV NS4A on IFN production could occur in the scenario of actual viral infection.