IGFBP7 and thyroid tumor: Since IGFBP7 is a secretory protein that could be easily detected in clinical specimens such as blood, it is of great interest to detect levels of serum IGFBP7 in patients with benign thyroid adenoma or malignant thyroid carcinoma of various subtypes, such that serum IGFBP7 levels might be used as valuable biomarkers for the early diagnosis and clinical therapy of thyroid neoplasms.