Notably, while four out of five mice inoculated with vector control WRO cells presented detectable tumor xenografts, only two out of five mice inoculated with WRO-IGFBP7 cells presented tumor growth (Fig. 3b), suggesting that IGFBP7 overexpression apparently suppressed not only the tumor growth rate, but also the tumorigenicity of thyroid cancer cells. Here, IGFBP7 is linked to neoplasm.