To determine the protein levels of IGFBP7 in different subtypes of thyroid tumors, we employed immunohistochemical staining in our collection of 112 paraffin-embedded, archived thyroid neoplasm specimens, including 18 cases of thyroid adenoma, 63 cases of papillary thyroid carcinoma (PTC), 15 cases of follicular thyroid carcinoma (FTC), and 16 cases of anaplastic thyroid carcinoma (ATC). The gene discussed is IGFBP7; the disease is differentiated thyroid carcinoma.