These data showed that the expression of IGFBP7 was significantly lower or even absent in FTC and ATC as compared with that in normal thyroid tissues, benign thyroid tumors and classical PTC, suggesting that IGFBP7 may represent a valuable biomarker for well-differentiated and poorly differentiated thyroid carcinoma. Here, IGFBP7 is linked to benign thyroid gland neoplasm.