NFE2L2 and fibrosis: As depicted in the results, in vivo studies indicated that licorice alleviate pulmonary edema and fibrosis, decrease MDA contents and increase SOD activity in PQ-induced ALI mice, protect the morphologic appearance of lung tissues, induce CYA3A4 and Nrf2 expression to active detoxification pathways, reduce the accumulation of PQ in vivo, protect or improve the liver and renal function of mice, and increase the survival rate.