The reduction of various parameters, including the density and size of adipocyte cells in both visceral and subcutaneous areas, adiposity index, MDA level, TNF-α, and NF-KB together with the increase in SOD, CAT, and GSH-Px activities and PPAR-γ in adipose tissue were also observed in OVX rats which were induced metabolic syndrome by HCHF diet and received MME. The gene discussed is NFKB1; the disease is metabolic syndrome.