SDC1 protein was highly expressed in adjacent non-neoplastic colorectal tissue homogenates but was weak or undetectable in CRC tissues (Figure 1(b), dimer, p = 0.0031; Figure 1(c), tetramer, p = 0.0134); SDC1 mRNA expression was decreased in CRC tissues compared to that in paired, adjacent non-neoplastic colorectal tissues (Figure 1(d), p < 0.001). This evidence concerns the gene SDC1 and colorectal carcinoma.