Effective new therapies target the T-cell inhibitory immune checkpoint receptors (including the cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and Programmed Death 1 (PD-1) receptors on lymphocytes), or the MAPK-signaling pathway in patients with BRAFV600 mutant melanoma, as well as more recently talimogene laherparepvec (T-VEC, the first approved oncolytic virotherapy for cancer offering a survival benefit in patients with stage IV-M1a). This evidence concerns the gene CTLA4 and melanoma.