Human pulmonary microvascular endothelial cells (HPMECs) are an important component of the vascular endothelial barrier, which is a semiselective permeable barrier that regulates the exchange of blood, fluid, proteins, and electrolytes across the vascular wall [3]; furthermore, Rab proteins play an important role in mediating endothelial barrier function and inflammation in acute respiratory distress syndrome (ARDS) [4–6]. The gene discussed is AGFG1; the disease is acute respiratory distress syndrome.