H&E staining of primary tumor sections further supported the observation that primary tumors in the “siELK3 LCM group” were poorly developed compared to those of the “siNS LCM group”, which suggests that the suppression of ELK3 in LECs restrained the promoting effect of LECs on tumor progression in MDA-MB-231 cells (Fig. 3B). This evidence concerns the gene ELK3 and neoplasm.