In summary, in this study, we experimentally established that (i) exosomes derived from LECs have pro-oncogenic activity; (ii) ELK3 determines the constituents of exosomes derived from LECs; and (iii) ELK3 from LECs regulates the expression of microRNAs that can promote or repress tumor progression and metastasis. Here, ELK3 is linked to neoplasm.