HSPA4 and bacterial infectious disease: Iryani et al., 2017 used RNAi to verify the role of HSP70 in protecting nauplii of A. franciscana against abiotic and biotic stressors., The survival of nauplii lacking HSP70, as compared to those containing the HSP70, was decreased 41% by heat stress and 34% upon Vibrio campbellii infection32 suggesting that HSP70plays an important role in maintaining protein homeostasis by functioning as molecular chaperones while enhancing the host innate immune system against bacterial infection.