SPAST and dementia: We identified 70 non-synonymous variants in the patients in 21 dementia-related genes, namely SIGMAR1, FUS, GRN, MAPT, ALS2, TAF15, FIG. 4, OPTN, DAO, HNRNPA1, PINK1, PARK7, SNCA, ATP13A2, PARK2, LRRK2, SPAST, SPG11, CSF1R, NOTCH3, and PRNP. In contrast, no missense mutation were found in TARDBP, CHMP2B, VCP, UBQLN2, SOD1, ANG, VAPB, SQSTM1, GBA, or CYP7B1 (Table S3).