Many similarities in genetic variants were reported between different neurodegenerative disorders, such as rare TREM2 variants in AD28, while TREM2 p.R47H was reported as a risk variant for PD, frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS)29,30. The gene discussed is TREM2; the disease is amyotrophic lateral sclerosis.