To assess early, CPS-induced molecular correlates of these potentially protective adaptive immune responses, we correlated expression values for each of the 20,525 most variable genes during the only two early, post-immunization time points that were not confounded by parasitemia (I1 Day +27 and I2 Day +27) with previously published data on the proportion of in vitro re-stimulated, P. falciparum-specific CD107a + CD4 T cells or granzyme B + CD8 T cells7 and IgG antibodies to CSP13 determined at 132 days after the third immunization (CHMI Day −1) in all subjects in the current study (n = 10). This evidence concerns the gene GZMB and parasitic infectious disease.