Recently, abnormal amplification of MAP3K3 has attracted widespread attention, and MAP3K3 overexpression has been shown to play a cancer-promoting role in different types, such as oesophageal squamous cell carcinoma, non-small cell lung cancer, pancreatic cancer, hepatocellular carcinoma, and renal clear cell carcinoma13–17. The gene discussed is MAP3K3; the disease is familial pancreatic carcinoma.