Mitogen-activated protein kinase kinase kinase 3 (MAP3K3), also known as mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 3 (MAP3K3/MEKK3), belongs to the MAP3K family of serine/threonine kinases, and its dysregulated expression plays a vital role in the occurrence, invasion, and metastasis of several types of cancers, including OC, breast cancer, kidney cancer, and oesophageal cancer4–7. The gene discussed is MAP3K3; the disease is breast cancer.