Importantly, when recombination of the floxed Shoc2 allele was analysed in remaining tumour nodules from Shoc2fl/fl KP mice, a band for the unrecombined Shoc2fl allele could be detected to various levels in a majority of these tumours (Fig. 1h) suggesting that at least a significant proportion of Shoc2fl/fl tumours after 6-months are ‘escapers’16,38,39 further underscoring the key requirement for SHOC2 in lung tumour development. The gene discussed is SHOC2; the disease is neoplasm.