Furthermore, we used Compound C to inhibit AMPK in vivo (Supplementary Fig. 8b), H&E staining showed that the lung, liver, spleen, heart, kidney and intestine were not significantly influenced by Compound C (Supplementary Fig. 12), the protective effects of cordycepin in radiation induced skin, intestine and tongue ulcers were significantly reversed (Supplementary Fig. 8c, d and Supplementary Fig. 3d), the survival rates in cordycepin with Compound C group were like those of the control group in radiation-induced intestine ulcer model (Supplementary Fig. 3e). The gene discussed is PRKAA1; the disease is intestinal disorder.