AKR1C1 and -C2 contribute 40% of the detoxification function of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in tobacco-derived nitrosamine carcinogens [17] In this study, we analyzed the HNSCC cell gene expression profiles and inhibitory concentration (IC50) of cisplatin from the CCLE and GDSC databases. The gene discussed is AKR1C1; the disease is head and neck squamous cell carcinoma.