Consistently, results from the Western blot analysis of tumor tissues indicated that mesenchymal markers (Snail, Slug and N-cadherin) were downregulated while epithelial marker (E-cadherin) was upregulated following SPOCK1 depletion and API treatment but upregulated E-cadherin, an epithelial marker in. The gene discussed is SNAI2; the disease is neoplasm.