Additionally, neurexin 2α, GluA4-containing glutamate receptor, and neuroligin 1, all proteins essential for long-term potentiation processes, are all significantly lower in NDEVs of patients 6–11 years prior to AD diagnosis and, along with neuronal pentraxin 2, are all downregulated in NDEVs of AD patients [73]. The gene discussed is NLGN1; the disease is Alzheimer disease.