NOTCH3 and neoplasm: To further study the role of Notch3 and its ligand Jag1 in EC-tumor interaction, we silenced Jag1 expression on E4+ECs using siRNA (Fig. 2g) and showed an inhibition of APOCC or OVCAR3 proliferation in co-cultures with E4+ECssiJag1 (Fig. 2h).