ICOS and sarcoidosis: Interestingly, a recent study that analyzed samples from airways obtained by BAF, Tregs from the lung of sarcoidosis patients were characterized by expressing high levels of the receptor CD278 on their surface and such a CD278 expressing Tregs cells were restricted to the inflamed lungs and were absent in blood Tregs of sarcoidosis patients as well as in lung and blood Tregs of healthy volunteers.