Moreover, given the structural similarities of certain mycobacterial proteins, especially heat shock proteins of mycobacterium tuberculosis (mTB-hsp) with human heat shock proteins (HSPs), it has been proposed that the exposure to mycobacterial antigens, via either natural infection, or by vaccination with BCG, may trigger an autoimmune response leading to sarcoidosis, in genetically prone individuals [36]. Here, HSP90B2P is linked to infection.