For example, higher percentages of CD8(+) αβ (+) T-cells, with a concomitant increase in the release of pro-inflammatory cytokines was observed when peripheral blood mononuclear cells (PBMCs) from patients with sarcoidosis were stimulated in vitro with Mtb-hsp, in comparison with PBMCs from controls or from patients with tuberculosis [42]. This evidence concerns the gene CD8A and sarcoidosis.