A comprehensive assessment of immune infiltration of sarcoidosis or tuberculosis granulomas using immunohistochemistry revealed that, although there was no significance difference in single CD4+, CD8+, CD22+, CD14+ and CD68+ staining between sarcoidosis and tuberculosis sections, CD163 expression (a marker of M2 macrophages) was significantly increased in sarcoidosis sections compared with those from tuberculosis [136]. This evidence concerns the gene CD4 and tuberculosis.