We found that both BRCA1 and BRCA2-mutated tumors had significantly more indels (Wilcoxon test, p = 1.6 × 10− 5 for BRCA1 and p = 1.4 × 10− 3 for BRCA2) and structural variants (Wilcoxon test, p = 5.1 × 10− 7 for BRCA1 and p = 0.029 for BRCA2) per tumor than the sporadic tumors. This evidence concerns the gene BRCA1 and neoplasm.