HMGB1 and lung disorder: Inflammation seen in smoking related lung disease is triggered in part by receptor for advanced glycation end-products (RAGE) [1] a multiligand receptor that is expressed by parenchymal lung cells, vascular cells, and inflammatory cells and binds to oxidized proteins and lipids, as well as the ligands high mobility group box 1 (HMGB1), S100A8, S100A9, and S100A12 in response to smoke and pollutant exposure [2–15].