Similarly, CTRP9 (determined dichotomously, adjusted for hypertension, diabetes, LVEF> 25%, NT-proBNP< 20,000 ng/L, diastolic pressure and total cholesterol) was also found to be independently predictive of death with a hazard risk ratio of 1.98 (95% CI 1.02 to 3.85, P = 0.044) and a predictor of free of HFrEF hospitalization with a hazard risk ratio of 2.67 (95% CI 1.58 to 4.50, P < 0.001). The gene discussed is NPPB; the disease is diabetes mellitus.