HSPA8 and Parkinson disease: Interestingly, these miRNAs, such as miR106a, miR320a, and miR301 (for Hsc70), or miR224 and miR373 (for LAMP-2A) levels are upregulated in the SN of PD patients, suggesting a CMA-mediated α-syn clearance defect in pathological conditions that could be involved in their accumulation and aggregation.