Corroborating this data, Murphy et al. (2015) showed that decreased levels of LAMP-2A and Hsc70 were associated with α-syn accumulation at the early stages of PD [51], and α-Syn protein was also shown to be colocalized with Hsc70 in the oligodendrocytes from MSA brains [52], confirming an impairment in the CMA machinery. This evidence concerns the gene HSPA8 and multiple system atrophy.