The most striking example highlighting an ALP impairment associated with α-syn accumulation in synucleinopathies is the presence of the microtubule-associated protein 1A/1B-light chain 3 (LC3), an autophagosomal marker, within the LB of PD brains and within the GCI of MSA brains. The gene discussed is MAP1LC3A; the disease is synucleinopathy.