Tanji and colleagues further demonstrated a decreased expression of the GABARAP gene encoding for the Gamma-aminotubyric acid receptor-associated protein and the GABARAPL2 gene encoding for the Golgi-associated ATPase enhancer of 16KDa (GATE-16), which both play important roles in autophagosome formation associated with impaired maturation of the proteins in the cerebellum of MSA patients [41]. Here, GABARAPL2 is linked to multiple system atrophy.