PIK3CA and cancer: An example is miR-379, which downregulates MDM2, thus preventing the ubiquitination and degradation of p53 [120]; PDK1, which is the convergence point of cancer signaling pathways such as the PI3K/Akt, Ras/MAPK and Myc pathways [121]; and COX-2, which inhibits the transition from acute to chronic inflammation and thereby prevents cancer initiation and progression [122].