Treatment of breast cancer cells with PTHrP67–86 upregulated the expression of several stress related genes, including heat shock factor binding protein-1 (hsbp1) and heat shock protein 90 (hsp-90), that sequester and inactivate heat shock factor -1 (hsf1), a protein that normally recognizes ETS transcription factor binding sites within gene promoters [83]. The gene discussed is HSBP1; the disease is breast carcinoma.