Gained expression of CD57, also known as HNK-1 (human natural killer-1), is a common feature associated with circulating senescent T cells, and increased CD8+CD28−CD57+ senescent T cells were identified in multiple pathological conditions, including HIV infection, multiple myeloma, lung cancer, and chronic inflammation conditions such as diabetes and obesity [99,114,115]. Here, CD8A is linked to lung carcinoma.